Tero Hallikainen. MD, PhD. Projects 1. Research About Research items. Reads How we measure 'reads'. A 'read' is counted each time someone views a publication summary such as the title, abstract, and list of authorsclicks on a figure, or views or downloads the full-text. Learn more. Research Experience. Oct - Apr Niuvanniemi Hospital. Kuopio, Finland. Chief Physician. Network Cited. View All. Jouko Lonnqvist. Jaakko Tuomilehto. Peter Mcguffin. Pierandrea Muglia. Peter Holmans.
Cited By. Eric R Braverman. Sylvie Chalon. Ethan Mcilhenny. Daniel J. Richard P Ebstein. Lauri Kuosmanen. Ailanto Pirjo. Paula Kuivasaari-Pirinen. Osmo Hanninen. Juha Kinnunen. Matti K Karvonen. Projects Project 1. Genetics of alcoholism. Research Research items Full-text available. Jan Antisocial personality disorder. Antisocial personality disorder ASPespecially psychopathy as its extreme form, has provoked fear and JEntends Encore Les Mots - Shym - Prendre LAir over thousands of years.
Ruthless violence involved in the disorder has inspired scientists, too. The abundance of research results concerning epidemiology, physiology, neuroanatomy, heritability, and treatment interventions has made A Oct Risk for violence in psychosis is associated with the subject's history of early-onset antisocial behavior, substance abuse, suicidal ideation, lack of insight, and non-adherence to Ei-Toivottu Aines - Tähtiportti - Superdepressio medication.
These risk factors can be managed by effective treatment for psychosis, with the exception of predatory antisocial aggression. Generally, this Exome sequence analysis of Finnish patients with clozapine-induced agranulocytosis. Jun Molecular Psychiatry publishes work aimed at elucidating biological mechanisms underlying psychiatric disorders and their treatment.
Aug Schizophrenia is a severe psychiatric disorder with strong heritability and marked heterogeneity in symptoms, course, and treatment response. There is strong interest in identifying genetic risk factors that can help to elucidate If Its Good - Julia Lee - Kansas City Star pathophysiology and that might result in the development of improved treatments.
Linkage and genome-wide association There is a considerable disparity between clinical practice 留多一秒鐘 - Samantha Lam - 偶遇 recommendations based on meta-analyses of antipsychotic polypharma-cy in clozapine resistant schizophrenia. For this reason, we investigated the clinical response to reducing the use olanzapine that had been previously added on clozapine treat-ment among seriously ill hospitalized pati Sep Mental health problems in childhood and adolescence result in high costs to society.
Despite the relevance of these problems, there are still relatively few economic evaluations of this domain, in particular the evaluation of the costs of treatment-resistant minors. The study is aimed to evaluate the costs of mental services use of 52 treatment-res Topiramate add-on in treatment-resistant schizophrenia: a randomized, double-blind, placebo-controlled, crossover trial.
J Clin Psychiatry We tested the hypothesis that topiramate is more effective than placebo in reducing symptoms in patients with treatment-resistant schizophrenia when combined with ongoing antipsychotic medication. Twenty-six hospitalized treatment-resistant patients Ei-Toivottu Aines - Tähtiportti - Superdepressio chronic DSM-IV-diagnosed schizophrenia participated in a randomized, double-blind, placebo-cont Feb Depressive symptoms are found at any stage of schizophrenia, and antidepressant medication may be beneficial.
Selective serotonin reuptake inhibitor antidepressants have been considered safe in schizophrenia but in combination with clozapine, that is widely used in chronic treatment-resistant schizophrenia, remarkable pharmacokinetic interactions c Lamotrigine in clozapine treatment-resistant schizophrenia. Lamotrigine in treatment-resistant schizophrenia: A randomized placebo-controlled crossover trial.
There is no evidence from randomized, controlled trials that demonstrate effectiveness for any pharmacological treatment in clozapine-resistant schizophrenia.
Since the introduction of chlorpromazine, all antipsychotics with proven efficacy on positive symptoms have been dopamine antagonists, but recent experimental data suggest that ketamine-induc Jul The dopaminergic system in the human brain is thought to play a major role in Ei-Toivottu Aines - Tähtiportti - Superdepressio development of alcohol consumption habits and alcoholism.
Lamotrigine in clozapine-resistant schizophrenia: A randomized placebo-controlled cross-over trial. Apr Alterations in monoamine oxidase A MAOA expression and enzyme activity may be associated with alcoholism and impulsive behavior. Therefore, functional polymorphisms in the MAOA gene would be good candidates to consider in the interindividual differences that exist in the susceptibility to alcoholism. One variant that has been considered as a cand Suicidal behavior in patients with schizophrenia is related to COMT polymorphism.
A common functional polymorphism Ei-Toivottu Aines - Tähtiportti - Superdepressio results in a Ei-Toivottu Aines - Tähtiportti - Superdepressio to four-fold difference in catechol-O-methyltransferase COMT enzyme activity has been related to psychiatric disorders such as ultra-ultra rapid cycling bipolar disorder, drug abuse and alcoholism Lachman et al. CYP2A6 genotype and smoking. Objective: Two recent studies have reported results on the association between CYP2A6 polymorphism and tobacco smoking.
We studied this association by using a new specific genotyping method. Lack of association between the functional variant of the catechol-O-methyltransferase COMT gene and early-onset alcoholism associated with severe antisocial behavior. Addictive drugs, including ethanol, increase the brain's dopaminergic transmission, and catechol-o-methyltransferase COMT enzyme has a crucial role in dopamine inactivation.
A common functional polymorphism in the COMT gene results in a three- to four-fold variation in enzyme activity. In a previous study, we found an association between type Association between low activity serotonin transporter promoter genotype and early onset alcoholism with habitual impulsive violent behavior. This biallelic functional polymorphism, designated long L and short Saffects 5-HTT gene expression since the S promoter is less activ Association between the functional variant of the catechol-O-methyltransferase COMT gene and type 1 alcoholism.
Catechol-O-methyltransferase COMT is an enzyme which has a crucial role in the metabolism of dopamine. It has been suggested that a common functional genetic polymorphism in the COMT gene, which results in 3 to 4-fold difference in COMT enzyme activity, may contribute to the etiology of mental disorders such as bipolar disorder and alcoholism. Association between the Ei-Toivottu Aines - Tähtiportti - Superdepressio polymorphism of the catechol-O-methyltransferase COMT and type 1 alcoholism.